Volume 3 (2016): Issue 2

Prevention of bleeding in patients with haemophilia undergoing surgery

Open Access | | Creative Commons Attribution NonCommercial NoDerivatives
Anne Wareing

Abstract

Abstract

There is little evidence on which to define the best treatment for the prevention of bleeding in people with congenital bleeding disorders undergoing surgery. As a result, treatment regimens are frequently based on local protocols developed by expert clinicians and information from uncontrolled observational studies. This article summarises the Cochrane Cystic Fibrosis and Genetic Disorders Group systematic review on ‘Treatment for preventing bleeding in people with haemophilia or other congenital bleeding disorders (CBDs) undergoing surgery’.

Article

View Full Article

References

  • 1. Coppola A, Windyga J, Tufano A, Yeung C, Di Minno MND. Treatment for preventing bleeding in people with haemophilia or other congenital bleeding disorders undergoing surgery. Cochrane Database of Systematic Reviews 2015;2:CD009961. doi: 10.1002/14651858.CD009961.pub2.
  • 2. Forbes CD, Barr RD, Reid G et al. Tranexamic acid in control of haemorrhage after dental extraction in haemophilia and Christmas disease. Br Med J 1972;2(5809):311–3.
  • 3. Walsh PN, Rizza CR, Matthews JM, et al. Epsilon-Aminocaproic acid therapy for dental extractions in haemophilia and Christmas disease: a double blind controlled trial. Br J Haematol 1971;20(5):463–75.
  • 4. Pruthi RK, Mathew P, Valentino LA, et al. Haemostatic efficacy and safety of bolus and continuous infusion of recombinant factor VIIa are comparable in haemophilia patients with inhibitors undergoing major surgery. Results from an open-label, randomized, multicenter trial. Thrombosis and Haemostasis 2007;98(4):726–32.
  • 5. Shapiro AD, Gilchrist GS, Hoots WK, Cooper HA, Gastineau DA. Prospective, randomised trial of two doses of rFVIIa (NovoSeven) in haemophilia patients with inhibitors undergoing surgery. Thrombosis and Haemostasis 1998;80(5):773–8.
  • 6. Srivastava A, Brewer AK, Mauser-Bunschoten P, et al. Guidelines for the management of haemophilia. Haemophilia. 2013;19(1):e1–47.
  • Higgins, J.P. and Green, S. eds., (2008). Cochrane handbook for systematic reviews of interventions (Vol. 5). Chichester: Wiley-Blackwell.

PDF Download

Download PDF

Open in full-page viewer

Authors

  • Anne Wareing

    anne.wareing@nhs.net
    Clinical Nurse Specialist, Department of Haemostasis, St George’s Univerity Hospital NHS Foundation Trust, Blackshaw Road, London SW17 0QT, UK