New challenges for an expanding generation of older persons with haemophilia

Jamie O’Hara; Declan Noone; Persefoni Kritikou; Karl-Johan Myren; Steve Chaplin; Daniel P Hart

doi:10.2478/jhp-2022-0001

Abstract

Abstract Background

Increasing survival among people with haemophilia means that more individuals are at risk of developing age-related morbidity. Little is known about morbidity and health-related quality of life (HRQoL) in different age groups within a single large population of people with haemophilia.

Aim

This study aimed to explore the association between increasing age and comorbidity among people with haemophilia and to compare their HRQoL with that of a sample of the general population in England.

Methods

The prevalence of comorbidity recorded in medical records and HRQoL assessed by EQ-5D were compared by age group in participants in the Cost of Haemophilia in Europe: A Socioeconomic Survey study (CHESS) in Europe. HRQoL was compared with that of a sample of the general population taken from the 2012 Health Survey for England (HSE).

Results

Younger adults in CHESS were more likely to have received prophylaxis from an early age. The mean number of affected joints in younger adults was 1.0; participants aged 41–50 (1.25) and 51–60 years (1.41) had the highest mean number of affected joints. The prevalence of comorbidity was 36% in patients aged 18–30, 61% in 31–60-year-olds and 68% in those aged 61+. HRQoL impairment in young adults with haemophilia was comparable with that in the HSE population aged over 60.

Conclusions

Older people with haemophilia have impaired quality of life compared with younger adults and an increasing prevalence of several age-related disorders affecting mental health and cardiovascular and bone health. Young adults with haemophilia report impaired HRQoL comparable with that in a general population aged 61+.

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Authors

Jamie O’Hara

jamie@hcdeconomics.com

University of Chester ; HCD Economics, UK .
Declan Noone
Persefoni Kritikou

Swedish Orphan Biovitrum AB, Sweden
Karl-Johan Myren

Swedish Orphan Biovitrum AB, Sweden
Steve Chaplin

HCD Economics, UK
Daniel P Hart

The Royal London Hospital Haemophilia Centre, Barts and the London School of Medicine and Dentistry, QMUL, UK